Drug interactions
Desvenlafaxine + Lomitapide
Severity: Minor
Desvenlafaxine and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is only a weak CYP3A4 inhibitor, and it is mainly cleared by conjugation, so any rise in lomitapide exposure is expected to be small. Lomitapide is a sensitive CYP3A4 substrate, and higher levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. The clinical significance is probably limited.
What this interaction means in plain words
Desvenlafaxine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated lomitapide metabolism by desvenlafaxine.
What to do
Keep lomitapide at the dose set by its labeling and monitor ALT, AST and bilirubin as routinely required. Reassess if gastrointestinal intolerance or liver enzyme elevation appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Lomitapide?
MediHelp rates the interaction as minor. Desvenlafaxine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is only a weak CYP3A4 inhibitor, and it is mainly cleared by conjugation, so any rise in lomitapide exposure is expected to be small. Lomitapide is a sensitive CYP3A4 substrate, and higher levels increase the risk of hepatotoxicity and gastrointestinal adverse effects. The clinical significance is probably limited.
How serious is the interaction between Desvenlafaxine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep lomitapide at the dose set by its labeling and monitor ALT, AST and bilirubin as routinely required. Reassess if gastrointestinal intolerance or liver enzyme elevation appears.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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