Drug interactions
Desvenlafaxine + Lonafarnib
Severity: Minor
Desvenlafaxine and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and desvenlafaxine is only a minor, weak CYP3A4 inhibitor, so any rise in lonafarnib exposure is likely small. Lonafarnib's effect on the QT interval is not well characterised, so higher exposure could matter for patients with cardiac risk factors.
What this interaction means in plain words
Desvenlafaxine and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A4-mediated lonafarnib metabolism by desvenlafaxine, which is not well established clinically.
What to do
No routine dose change is needed; keep lonafarnib at the labeled dose and ask the patient to report palpitations or syncope. Consider an ECG if other QT-prolonging drugs or electrolyte disturbances are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Lonafarnib?
MediHelp rates the interaction as minor. Desvenlafaxine and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate and desvenlafaxine is only a minor, weak CYP3A4 inhibitor, so any rise in lonafarnib exposure is likely small. Lonafarnib's effect on the QT interval is not well characterised, so higher exposure could matter for patients with cardiac risk factors.
How serious is the interaction between Desvenlafaxine and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; keep lonafarnib at the labeled dose and ask the patient to report palpitations or syncope. Consider an ECG if other QT-prolonging drugs or electrolyte disturbances are present.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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