Drug interactions
Desvenlafaxine + Metoprolol
Severity: Minor
Desvenlafaxine and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, mainly at higher doses, and may slightly raise metoprolol exposure. The clinical effect is usually small, though bradycardia or hypotension may occur.
What this interaction means in plain words
Desvenlafaxine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Weak, dose-dependent CYP2D6 inhibition by desvenlafaxine reduces metoprolol metabolism.
What to do
Monitor heart rate and blood pressure, especially with higher desvenlafaxine doses, and reduce the metoprolol dose if symptomatic bradycardia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Metoprolol?
MediHelp rates the interaction as minor. Desvenlafaxine and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, mainly at higher doses, and may slightly raise metoprolol exposure. The clinical effect is usually small, though bradycardia or hypotension may occur.
How serious is the interaction between Desvenlafaxine and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, especially with higher desvenlafaxine doses, and reduce the metoprolol dose if symptomatic bradycardia develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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