Drug interactions
Desvenlafaxine + Promethazine
Severity: Minor
Desvenlafaxine and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak to moderate CYP2D6 inhibitor at higher doses and may modestly raise levels of promethazine, which is partly metabolized by CYP2D6. The expected result is somewhat greater sedation or anticholinergic effect, usually of limited clinical importance.
What this interaction means in plain words
Desvenlafaxine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Inhibition of CYP2D6-mediated promethazine metabolism by desvenlafaxine.
What to do
No routine dose change is needed; monitor for increased sedation or anticholinergic effects when desvenlafaxine doses are high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Promethazine?
MediHelp rates the interaction as minor. Desvenlafaxine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak to moderate CYP2D6 inhibitor at higher doses and may modestly raise levels of promethazine, which is partly metabolized by CYP2D6. The expected result is somewhat greater sedation or anticholinergic effect, usually of limited clinical importance.
How serious is the interaction between Desvenlafaxine and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased sedation or anticholinergic effects when desvenlafaxine doses are high.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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