Drug interactions
Desvenlafaxine + Tazemetostat
Severity: Minor
Desvenlafaxine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is cleared mainly by CYP3A4, and desvenlafaxine is only a weak CYP3A inhibitor. Any increase in tazemetostat exposure is expected to be small. Clinical relevance is likely minimal.
What this interaction means in plain words
Desvenlafaxine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4 by desvenlafaxine could marginally raise tazemetostat concentrations.
What to do
No dose adjustment is generally needed. Monitor for tazemetostat adverse effects as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Desvenlafaxine with Tazemetostat?
MediHelp rates the interaction as minor. Desvenlafaxine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is cleared mainly by CYP3A4, and desvenlafaxine is only a weak CYP3A inhibitor. Any increase in tazemetostat exposure is expected to be small. Clinical relevance is likely minimal.
How serious is the interaction between Desvenlafaxine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for tazemetostat adverse effects as routine.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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