Drug interactions
Deutetrabenazine + Eszopiclone
Severity: Moderate
Deutetrabenazine and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and sedation, so using them together may increase drowsiness, impaired psychomotor performance and next-day impairment. Patients may be at higher risk of falls and accidents.
What this interaction means in plain words
Deutetrabenazine and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Eszopiclone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Start eszopiclone at the lowest dose and monitor for excessive sedation. Advise patients to avoid driving or hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deutetrabenazine and Eszopiclone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eszopiclone
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Eszopiclone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and sedation, so using them together may increase drowsiness, impaired psychomotor performance and next-day impairment. Patients may be at higher risk of falls and accidents.
How serious is the interaction between Deutetrabenazine and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at the lowest dose and monitor for excessive sedation. Advise patients to avoid driving or hazardous tasks until the response is known.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
