Drug interactions
Deutetrabenazine + Loxapine
Severity: Moderate
Deutetrabenazine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce dopaminergic transmission, so combining them can increase the risk of parkinsonism, akathisia, and rarely neuroleptic malignant syndrome. Additive sedation and QT effects may also occur.
What this interaction means in plain words
Deutetrabenazine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism (loxapine at D2 receptors) and presynaptic monoamine depletion (VMAT2 inhibition by deutetrabenazine).
What to do
Use the lowest effective doses and monitor for extrapyramidal symptoms, sedation, and hyperthermia with rigidity. Consider an ECG if other QT-prolonging drugs are present, and reduce doses if movement symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Loxapine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce dopaminergic transmission, so combining them can increase the risk of parkinsonism, akathisia, and rarely neuroleptic malignant syndrome. Additive sedation and QT effects may also occur.
How serious is the interaction between Deutetrabenazine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for extrapyramidal symptoms, sedation, and hyperthermia with rigidity. Consider an ECG if other QT-prolonging drugs are present, and reduce doses if movement symptoms emerge.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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