Drug interactions
Deutetrabenazine + Memantine-donepezil
Severity: Moderate
Deutetrabenazine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval, and deutetrabenazine has a small QT effect at higher exposures or when metabolism is impaired. Risk is greater with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Correct potassium and magnesium abnormalities and obtain an ECG in patients with additional QT risk factors. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Deutetrabenazine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval, and deutetrabenazine has a small QT effect at higher exposures or when metabolism is impaired. Risk is greater with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium abnormalities and obtain an ECG in patients with additional QT risk factors. Avoid adding further QT-prolonging drugs.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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