Drug interactions
Deutetrabenazine + Primaquine
Severity: Moderate
Deutetrabenazine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primaquine can prolong the QT interval, and deutetrabenazine has minimal QT effect at recommended doses but may add to the effect at higher exposure. The risk is mainly in patients with other QT risk factors.
What this interaction means in plain words
Deutetrabenazine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Possible additive prolongation of cardiac repolarization.
What to do
Check ECG in patients with bradycardia, electrolyte abnormalities or congenital long QT, and correct potassium and magnesium. Avoid exceeding recommended deutetrabenazine doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Primaquine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primaquine can prolong the QT interval, and deutetrabenazine has minimal QT effect at recommended doses but may add to the effect at higher exposure. The risk is mainly in patients with other QT risk factors.
How serious is the interaction between Deutetrabenazine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG in patients with bradycardia, electrolyte abnormalities or congenital long QT, and correct potassium and magnesium. Avoid exceeding recommended deutetrabenazine doses.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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