Drug interactions
Deutetrabenazine + Propafenone
Severity: Moderate
Deutetrabenazine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, though deutetrabenazine does so only modestly at recommended doses. Risk of torsades de pointes rises with bradycardia, electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive QT prolongation; deutetrabenazine metabolites are also CYP2D6 substrates, and propafenone inhibits CYP2D6.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor QTc, and limit the deutetrabenazine dose when used with a strong CYP2D6 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Propafenone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, though deutetrabenazine does so only modestly at recommended doses. Risk of torsades de pointes rises with bradycardia, electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor QTc, and limit the deutetrabenazine dose when used with a strong CYP2D6 inhibitor.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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