Drug interactions
Deutetrabenazine + Quetiapine
Severity: Moderate
Deutetrabenazine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect dopaminergic signaling, so combined use may increase parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Sedation, depression and QT effects may also add.
What this interaction means in plain words
Deutetrabenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism and depletion of presynaptic monoamines, with additive sedative and QT effects.
What to do
Monitor for extrapyramidal symptoms, akathisia, sedation, mood changes and ECG changes. Adjust the deutetrabenazine or quetiapine dose if movement symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Quetiapine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents affect dopaminergic signaling, so combined use may increase parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Sedation, depression and QT effects may also add.
How serious is the interaction between Deutetrabenazine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, akathisia, sedation, mood changes and ECG changes. Adjust the deutetrabenazine or quetiapine dose if movement symptoms emerge.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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