Drug interactions
Deutetrabenazine + Quinidine
Severity: Major
Deutetrabenazine and Quinidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. Both agents can also prolong the QT interval, adding to arrhythmia risk, and higher exposure raises sedation, depression and parkinsonism risk.
What this interaction means in plain words
Deutetrabenazine and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP2D6 metabolism of deutetrabenazine's active metabolites, with additive QT prolongation.
What to do
Limit deutetrabenazine to no more than 36 mg daily (18 mg per dose) and monitor ECG QTc and neuropsychiatric effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Quinidine?
MediHelp rates the interaction as major. Deutetrabenazine and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. Both agents can also prolong the QT interval, adding to arrhythmia risk, and higher exposure raises sedation, depression and parkinsonism risk.
How serious is the interaction between Deutetrabenazine and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to no more than 36 mg daily (18 mg per dose) and monitor ECG QTc and neuropsychiatric effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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