Drug interactions
Deutetrabenazine + Sertraline
Severity: Moderate
Deutetrabenazine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, although the effect of each at usual doses is modest. Risk rises with additional factors such as bradycardia, electrolyte disturbances, congenital long QT, or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Correct potassium and magnesium before and during therapy and obtain an ECG in patients with additional QT risk factors. Avoid adding further QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Sertraline?
MediHelp rates the interaction as moderate. Deutetrabenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, although the effect of each at usual doses is modest. Risk rises with additional factors such as bradycardia, electrolyte disturbances, congenital long QT, or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and obtain an ECG in patients with additional QT risk factors. Avoid adding further QT-prolonging drugs where possible.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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