Drug interactions
Deutetrabenazine + Thioridazine
Severity: Major
Deutetrabenazine and Thioridazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect dopaminergic transmission, so combining them can increase the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Thioridazine is also a strong QT-prolonging agent, and deutetrabenazine may add modestly to QT risk, particularly in predisposed patients.
What this interaction means in plain words
Deutetrabenazine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism or depletion (D2 blockade plus VMAT2 inhibition) and additive QTc prolongation.
What to do
Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc periodically. Watch for extrapyramidal symptoms and hyperthermia or rigidity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Thioridazine?
MediHelp rates the interaction as major. Deutetrabenazine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs affect dopaminergic transmission, so combining them can increase the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Thioridazine is also a strong QT-prolonging agent, and deutetrabenazine may add modestly to QT risk, particularly in predisposed patients.
How serious is the interaction between Deutetrabenazine and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc periodically. Watch for extrapyramidal symptoms and hyperthermia or rigidity.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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