Drug interactions
Deutetrabenazine + Umeclidinium-vilanterol
Severity: Moderate
Deutetrabenazine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol can prolong the QT interval and deutetrabenazine has a modest QT effect, particularly at higher exposures. Together they may add to arrhythmia risk, especially with hypokalemia, bradycardia or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization.
What to do
Correct potassium and magnesium and obtain an ECG in patients with QT risk factors. Avoid in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Deutetrabenazine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol can prolong the QT interval and deutetrabenazine has a modest QT effect, particularly at higher exposures. Together they may add to arrhythmia risk, especially with hypokalemia, bradycardia or congenital long QT.
How serious is the interaction between Deutetrabenazine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain an ECG in patients with QT risk factors. Avoid in congenital long QT syndrome.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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