Drug interactions
Deutetrabenazine + Vardenafil
Severity: Moderate
Deutetrabenazine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil has modest QT-prolonging potential and deutetrabenazine may cause small QT increases, particularly at higher exposures. Risk is mainly in patients with other QT risk factors.
What this interaction means in plain words
Deutetrabenazine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Potential additive QT interval prolongation.
What to do
Obtain a baseline ECG and monitor in patients with bradycardia, electrolyte disturbances, or other QT-prolonging drugs. Correct potassium and magnesium first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Vardenafil?
MediHelp rates the interaction as moderate. Deutetrabenazine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil has modest QT-prolonging potential and deutetrabenazine may cause small QT increases, particularly at higher exposures. Risk is mainly in patients with other QT risk factors.
How serious is the interaction between Deutetrabenazine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor in patients with bradycardia, electrolyte disturbances, or other QT-prolonging drugs. Correct potassium and magnesium first.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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