Drug interactions
Deutetrabenazine + Ziprasidone
Severity: Major
Deutetrabenazine and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect dopaminergic transmission, and combining a dopamine antagonist with a VMAT2 inhibitor increases the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Sedation and QT effects may also be additive, and deutetrabenazine labeling advises caution with QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deutetrabenazine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 blockade and presynaptic dopamine depletion, plus additive sedation and possible QT prolongation.
What to do
Monitor for movement disorders, rigidity, fever and mental status change, and obtain an ECG in patients with cardiac risk factors. Use the lowest effective doses of both drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Ziprasidone?
MediHelp rates the interaction as major. Deutetrabenazine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs affect dopaminergic transmission, and combining a dopamine antagonist with a VMAT2 inhibitor increases the risk of parkinsonism, akathisia and neuroleptic malignant syndrome. Sedation and QT effects may also be additive, and deutetrabenazine labeling advises caution with QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, rigidity, fever and mental status change, and obtain an ECG in patients with cardiac risk factors. Use the lowest effective doses of both drugs.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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