Drug interactions
Dexamethasone + Etravirine
Severity: Moderate
Dexamethasone and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower etravirine exposure through CYP3A4 induction, risking reduced antiviral efficacy with sustained use. Etravirine is itself an inducer and may lower dexamethasone exposure, reducing steroid effect.
What this interaction means in plain words
Dexamethasone and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Mutual induction of CYP3A4 by both drugs increases the metabolic clearance of the other.
What to do
Avoid prolonged systemic dexamethasone with etravirine where possible; if needed, monitor HIV viral load and clinical steroid response, adjusting the dexamethasone dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dexamethasone with Etravirine?
MediHelp rates the interaction as moderate. Dexamethasone and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower etravirine exposure through CYP3A4 induction, risking reduced antiviral efficacy with sustained use. Etravirine is itself an inducer and may lower dexamethasone exposure, reducing steroid effect.
How serious is the interaction between Dexamethasone and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with etravirine where possible; if needed, monitor HIV viral load and clinical steroid response, adjusting the dexamethasone dose as required.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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