Drug interactions
Dexamethasone + Hydrochlorothiazide-lisinopril
Severity: Moderate
Dexamethasone and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone and hydrochlorothiazide both promote potassium loss, so combined use can cause clinically significant hypokalemia. Corticosteroids may also raise blood pressure and counteract the antihypertensive effect.
What this interaction means in plain words
Dexamethasone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting; corticosteroid-related sodium and fluid retention opposes antihypertensive therapy.
What to do
Monitor serum potassium and blood pressure during corticosteroid therapy and supplement potassium if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Dexamethasone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone and hydrochlorothiazide both promote potassium loss, so combined use can cause clinically significant hypokalemia. Corticosteroids may also raise blood pressure and counteract the antihypertensive effect.
How serious is the interaction between Dexamethasone and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticosteroid therapy and supplement potassium if required.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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