Drug interactions
Dexamethasone + Lonafarnib
Severity: Moderate
Dexamethasone and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may increase dexamethasone exposure, raising the risk of corticosteroid adverse effects. Dexamethasone is also a CYP3A4 inducer and may reduce lonafarnib levels.
What this interaction means in plain words
Dexamethasone and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by lonafarnib reduces dexamethasone clearance; dexamethasone may induce lonafarnib metabolism.
What to do
Monitor for corticosteroid excess and consider reducing the dexamethasone dose; monitor lonafarnib tolerability and response during prolonged coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Dexamethasone with Lonafarnib?
MediHelp rates the interaction as moderate. Dexamethasone and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may increase dexamethasone exposure, raising the risk of corticosteroid adverse effects. Dexamethasone is also a CYP3A4 inducer and may reduce lonafarnib levels.
How serious is the interaction between Dexamethasone and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and consider reducing the dexamethasone dose; monitor lonafarnib tolerability and response during prolonged coadministration.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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