Drug interactions
Dexamethasone + Lornoxicam
Severity: Moderate
Dexamethasone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs both damage the gastric mucosa through different pathways, and together they raise the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients and with prolonged or high-dose use.
What this interaction means in plain words
Dexamethasone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects.
What to do
Use the shortest possible duration and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for dyspepsia and signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Dexamethasone with Lornoxicam?
MediHelp rates the interaction as moderate. Dexamethasone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs both damage the gastric mucosa through different pathways, and together they raise the risk of peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients and with prolonged or high-dose use.
How serious is the interaction between Dexamethasone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible duration and consider gastroprotection with a proton pump inhibitor in at-risk patients. Monitor for dyspepsia and signs of GI bleeding.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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