Drug interactions
Dexamethasone + Omeprazole
Severity: Minor
Dexamethasone and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and could slightly lower omeprazole exposure. Omeprazole is mainly cleared via CYP2C19, so this is unlikely to matter clinically.
What this interaction means in plain words
Dexamethasone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak induction of CYP3A4 by dexamethasone may modestly increase omeprazole metabolism.
What to do
No change needed; reassess acid control if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Omeprazole?
MediHelp rates the interaction as minor. Dexamethasone and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a CYP3A4 inducer and could slightly lower omeprazole exposure. Omeprazole is mainly cleared via CYP2C19, so this is unlikely to matter clinically.
How serious is the interaction between Dexamethasone and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change needed; reassess acid control if symptoms persist.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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