Drug interactions
Dexamethasone + Sonidegib
Severity: Moderate
Dexamethasone and Sonidegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a CYP3A4 inducer and may lower sonidegib plasma concentrations. Reduced exposure could compromise the antitumour efficacy of sonidegib in basal cell carcinoma.
What this interaction means in plain words
Dexamethasone and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Sonidegib belongs to Oncology.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolic clearance of sonidegib, which is a CYP3A substrate.
What to do
Short courses of dexamethasone (e.g. antiemetic use) are usually acceptable, but avoid prolonged use where possible and prefer a non-inducing alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Dexamethasone with Sonidegib?
MediHelp rates the interaction as moderate. Dexamethasone and Sonidegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone is a CYP3A4 inducer and may lower sonidegib plasma concentrations. Reduced exposure could compromise the antitumour efficacy of sonidegib in basal cell carcinoma.
How serious is the interaction between Dexamethasone and Sonidegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Short courses of dexamethasone (e.g. antiemetic use) are usually acceptable, but avoid prolonged use where possible and prefer a non-inducing alternative.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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