Drug interactions
Dexamethasone + Tipranavir
Severity: Moderate
Dexamethasone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and lower tipranavir concentrations, risking reduced antiviral efficacy. Tipranavir/ritonavir may also raise dexamethasone exposure.
What this interaction means in plain words
Dexamethasone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Dexamethasone-mediated CYP3A4 induction reduces tipranavir exposure, and ritonavir-boosted tipranavir affects dexamethasone clearance.
What to do
Monitor HIV viral load and tipranavir response when dexamethasone is used. Avoid prolonged high-dose courses where possible and watch for corticosteroid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dexamethasone with Tipranavir?
MediHelp rates the interaction as moderate. Dexamethasone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and lower tipranavir concentrations, risking reduced antiviral efficacy. Tipranavir/ritonavir may also raise dexamethasone exposure.
How serious is the interaction between Dexamethasone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and tipranavir response when dexamethasone is used. Avoid prolonged high-dose courses where possible and watch for corticosteroid toxicity.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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