Drug interactions
Dexamethasone + Voriconazole
Severity: Moderate
Dexamethasone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone can induce voriconazole metabolism and lower antifungal levels, risking treatment failure. Voriconazole may in turn raise dexamethasone exposure and steroid adverse effects.
What this interaction means in plain words
Dexamethasone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Dexamethasone induces CYP enzymes including CYP3A4 and CYP2C19, while voriconazole inhibits CYP3A4 metabolism of dexamethasone.
What to do
Monitor voriconazole trough concentrations and clinical response, adjusting the dose as needed. Watch for corticosteroid excess such as hyperglycemia and hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Dexamethasone with Voriconazole?
MediHelp rates the interaction as moderate. Dexamethasone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone can induce voriconazole metabolism and lower antifungal levels, risking treatment failure. Voriconazole may in turn raise dexamethasone exposure and steroid adverse effects.
How serious is the interaction between Dexamethasone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response, adjusting the dose as needed. Watch for corticosteroid excess such as hyperglycemia and hypokalemia.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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