Drug interactions
Dexamethasone-neomycin-polymyxin + Etravirine
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone induces CYP3A4 and may reduce etravirine concentrations, risking reduced antiviral efficacy. Etravirine, itself an inducer, may also lower dexamethasone exposure. The effect is most relevant with systemic or prolonged dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Etravirine belongs to Anti Virals.
Why it happens
Mutual CYP3A4 induction lowers concentrations of both drugs.
What to do
Monitor HIV viral load and the clinical corticosteroid response. Avoid prolonged systemic dexamethasone where an alternative is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Etravirine?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone induces CYP3A4 and may reduce etravirine concentrations, risking reduced antiviral efficacy. Etravirine, itself an inducer, may also lower dexamethasone exposure. The effect is most relevant with systemic or prolonged dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and the clinical corticosteroid response. Avoid prolonged systemic dexamethasone where an alternative is available.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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