Drug interactions
Dexamethasone-neomycin-polymyxin + Iloperidone
Severity: Minor
Dexamethasone-neomycin-polymyxin and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and reduce iloperidone exposure, whereas iloperidone is a weak CYP3A inhibitor and may slightly raise dexamethasone levels. Net effects are modest and relevant mainly with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Iloperidone belongs to Central Nervous System.
Why it happens
Opposing CYP3A4 effects: induction by dexamethasone and weak inhibition by iloperidone.
What to do
Monitor psychiatric response and corticosteroid adverse effects with prolonged systemic use. Adjust doses if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Iloperidone?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and reduce iloperidone exposure, whereas iloperidone is a weak CYP3A inhibitor and may slightly raise dexamethasone levels. Net effects are modest and relevant mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and corticosteroid adverse effects with prolonged systemic use. Adjust doses if clinically indicated.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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