Drug interactions
Dexamethasone-neomycin-polymyxin + Itraconazole
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and can raise dexamethasone exposure, increasing corticosteroid adverse effects such as Cushingoid features and adrenal suppression. Dexamethasone, as a CYP3A4 inducer, may lower itraconazole concentrations and reduce antifungal efficacy.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated dexamethasone clearance, while dexamethasone induces CYP3A4 and reduces itraconazole levels.
What to do
Monitor for corticosteroid excess and consider lowering the dexamethasone dose in prolonged systemic use. Check itraconazole trough levels and clinical response to the antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Itraconazole?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and can raise dexamethasone exposure, increasing corticosteroid adverse effects such as Cushingoid features and adrenal suppression. Dexamethasone, as a CYP3A4 inducer, may lower itraconazole concentrations and reduce antifungal efficacy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and consider lowering the dexamethasone dose in prolonged systemic use. Check itraconazole trough levels and clinical response to the antifungal.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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