Drug interactions
Dexamethasone-neomycin-polymyxin + Lomitapide
Severity: Minor
Dexamethasone-neomycin-polymyxin and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a P-glycoprotein inhibitor and could raise levels of P-gp substrates such as dexamethasone. With topical or ophthalmic dexamethasone, systemic exposure is too small for this to matter.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein efflux, potentially increasing dexamethasone absorption and exposure.
What to do
No action is needed for topical use; with systemic dexamethasone, watch for corticosteroid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lomitapide?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide is a P-glycoprotein inhibitor and could raise levels of P-gp substrates such as dexamethasone. With topical or ophthalmic dexamethasone, systemic exposure is too small for this to matter.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical use; with systemic dexamethasone, watch for corticosteroid adverse effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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