Drug interactions
Dexamethasone-neomycin-polymyxin + Lornoxicam
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs together increase the risk of GI ulceration and bleeding. This matters mainly with systemic dexamethasone exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from corticosteroids and NSAID inhibition of protective prostaglandins.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lornoxicam
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lornoxicam?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs together increase the risk of GI ulceration and bleeding. This matters mainly with systemic dexamethasone exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in at-risk patients.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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