Drug interactions
Dexamethasone-neomycin-polymyxin + Lovastatin
Severity: Minor
Dexamethasone-neomycin-polymyxin and Lovastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and modestly lower lovastatin exposure, possibly reducing lipid-lowering effect. Topical use of the combination product gives minimal exposure.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lovastatin belongs to Cardiovascular.
Why it happens
CYP3A4 induction by dexamethasone increases lovastatin metabolism.
What to do
No routine action is needed; check lipid response if prolonged systemic dexamethasone is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Lovastatin?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Lovastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone may induce CYP3A4 and modestly lower lovastatin exposure, possibly reducing lipid-lowering effect. Topical use of the combination product gives minimal exposure.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lovastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check lipid response if prolonged systemic dexamethasone is used.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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