Drug interactions
Dexamethasone-neomycin-polymyxin + Mefenamic acid
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with NSAIDs raise the risk of gastric ulceration and bleeding. The concern is mainly with systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Additive GI mucosal damage from corticosteroids and prostaglandin inhibition by the NSAID.
What to do
Limit duration of both and give gastroprotection with a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Mefenamic acid?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with NSAIDs raise the risk of gastric ulceration and bleeding. The concern is mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit duration of both and give gastroprotection with a proton pump inhibitor in higher-risk patients.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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