Drug interactions
Dexamethasone-neomycin-polymyxin + Midazolam
Severity: Moderate
Dexamethasone-neomycin-polymyxin and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may induce CYP3A4 and reduce midazolam exposure, potentially lessening sedation. The effect is more pronounced with oral midazolam and repeated dexamethasone dosing.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Midazolam belongs to Central Nervous System.
Why it happens
CYP3A4 induction by dexamethasone increases midazolam clearance and first-pass metabolism.
What to do
Titrate midazolam to clinical effect and expect higher dose requirements. Monitor sedation level and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Midazolam?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may induce CYP3A4 and reduce midazolam exposure, potentially lessening sedation. The effect is more pronounced with oral midazolam and repeated dexamethasone dosing.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect and expect higher dose requirements. Monitor sedation level and respiratory status.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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