Drug interactions
Dexamethasone-tobramycin + Fluconazole
Severity: Moderate
Dexamethasone-tobramycin and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and can raise dexamethasone exposure, increasing corticosteroid adverse effects such as hyperglycemia and adrenal suppression with systemic use. The effect is generally modest and less relevant with topical therapy.
What this interaction means in plain words
Dexamethasone-tobramycin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated dexamethasone metabolism by fluconazole.
What to do
With systemic dexamethasone, monitor for corticosteroid excess such as hyperglycemia and fluid retention, and reduce the dose if needed. No action is required for topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Fluconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Fluconazole?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and can raise dexamethasone exposure, increasing corticosteroid adverse effects such as hyperglycemia and adrenal suppression with systemic use. The effect is generally modest and less relevant with topical therapy.
How serious is the interaction between Dexamethasone-tobramycin and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor for corticosteroid excess such as hyperglycemia and fluid retention, and reduce the dose if needed. No action is required for topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
