Drug interactions
Dexamethasone-tobramycin + Hemin
Severity: Moderate
Dexamethasone-tobramycin and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may induce delta-aminolevulinic acid synthase and counteract hemin's suppression of porphyria attacks. This is mainly relevant to systemic dexamethasone.
What this interaction means in plain words
Dexamethasone-tobramycin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Hemin belongs to Miscellaneous.
Why it happens
Induction of hepatic ALA synthase opposes the therapeutic effect of hemin.
What to do
Avoid unnecessary systemic corticosteroids in acute porphyria and monitor clinical response to hemin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Hemin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids may induce delta-aminolevulinic acid synthase and counteract hemin's suppression of porphyria attacks. This is mainly relevant to systemic dexamethasone.
How serious is the interaction between Dexamethasone-tobramycin and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary systemic corticosteroids in acute porphyria and monitor clinical response to hemin.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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