Drug interactions
Dalteparin + Hemin
Severity: Moderate
Dalteparin and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin breakdown product hematin can cause transient anticoagulant effects and thrombocytopenia. Together with dalteparin this may increase bleeding tendency.
What this interaction means in plain words
Dalteparin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Hemin belongs to Miscellaneous.
Why it happens
Additive anticoagulant and platelet-related effects of hematin with heparin-mediated antithrombin activation.
What to do
Monitor for bleeding and check platelet count and coagulation status during hemin therapy in anticoagulated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
- Dexamethasone-neomycin-polymyxin + Hemin Moderate
Frequently asked questions
Can I take Dalteparin with Hemin?
MediHelp rates the interaction as moderate. Dalteparin and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin breakdown product hematin can cause transient anticoagulant effects and thrombocytopenia. Together with dalteparin this may increase bleeding tendency.
How serious is the interaction between Dalteparin and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check platelet count and coagulation status during hemin therapy in anticoagulated patients.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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