Drug interactions
Bazedoxifene-conjugated estrogens + Hemin
Severity: Moderate
Bazedoxifene-conjugated estrogens and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can precipitate attacks of acute porphyria by inducing hepatic heme synthesis. Estrogen therapy may therefore counteract the benefit of hemin in a patient with porphyria.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Hemin belongs to Miscellaneous.
Why it happens
Estrogens may induce delta-aminolevulinic acid synthase, increasing porphyrin precursor production that opposes hemin's repression of this enzyme.
What to do
Avoid estrogen-containing therapy in patients with acute porphyria where possible. If used, monitor for porphyria symptoms and porphyrin precursor levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
- Dexamethasone-neomycin-polymyxin + Hemin Moderate
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Hemin?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens can precipitate attacks of acute porphyria by inducing hepatic heme synthesis. Estrogen therapy may therefore counteract the benefit of hemin in a patient with porphyria.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing therapy in patients with acute porphyria where possible. If used, monitor for porphyria symptoms and porphyrin precursor levels.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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