Drug interactions
Dabigatran etexilate + Hemin
Severity: Moderate
Dabigatran etexilate and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin breakdown products can have mild anticoagulant and platelet effects, which may add to the bleeding tendency of dabigatran. The effect is usually modest and short term.
What this interaction means in plain words
Dabigatran etexilate and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Hemin belongs to Miscellaneous.
Why it happens
Additive anticoagulant effect; hematin from hemin degradation may impair coagulation.
What to do
Monitor for bleeding and coagulation parameters during hemin infusions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
- Dexamethasone-neomycin-polymyxin + Hemin Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Hemin?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin breakdown products can have mild anticoagulant and platelet effects, which may add to the bleeding tendency of dabigatran. The effect is usually modest and short term.
How serious is the interaction between Dabigatran etexilate and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters during hemin infusions.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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