Drug interactions
Argatroban + Hemin
Severity: Moderate
Argatroban and Hemin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hemin breaks down to hematin, which can cause mild anticoagulant effects and thrombocytopenia. Combined with argatroban this may increase bleeding tendency.
What this interaction means in plain words
Argatroban and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Hemin belongs to Miscellaneous.
Why it happens
Additive anticoagulant and platelet-lowering effects of hematin with thrombin inhibition.
What to do
Monitor aPTT, platelet count and for bleeding during and after hemin infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Hemin
- Hemin + Secobarbital Major
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
- Dexamethasone-neomycin-polymyxin + Hemin Moderate
Frequently asked questions
Can I take Argatroban with Hemin?
MediHelp rates the interaction as moderate. Argatroban and Hemin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hemin breaks down to hematin, which can cause mild anticoagulant effects and thrombocytopenia. Combined with argatroban this may increase bleeding tendency.
How serious is the interaction between Argatroban and Hemin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT, platelet count and for bleeding during and after hemin infusion.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
Full monographs, dosing and an interaction checker in the MediHelp app
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