Drug interactions
Dexamethasone-tobramycin + Idelalisib
Severity: Moderate
Dexamethasone-tobramycin and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may raise dexamethasone exposure, while systemic dexamethasone is a CYP3A inducer that may lower idelalisib exposure. With topical or ophthalmic dexamethasone, the effect is expected to be small.
What this interaction means in plain words
Dexamethasone-tobramycin and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Idelalisib belongs to Oncology.
Why it happens
Bidirectional CYP3A4 effects: idelalisib inhibits dexamethasone metabolism and dexamethasone induces idelalisib metabolism.
What to do
With systemic dexamethasone, monitor for corticosteroid excess and for reduced idelalisib response; no action is needed for minimal-absorption topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Idelalisib?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may raise dexamethasone exposure, while systemic dexamethasone is a CYP3A inducer that may lower idelalisib exposure. With topical or ophthalmic dexamethasone, the effect is expected to be small.
How serious is the interaction between Dexamethasone-tobramycin and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, monitor for corticosteroid excess and for reduced idelalisib response; no action is needed for minimal-absorption topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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