Drug interactions
Dexamethasone-tobramycin + Levoketoconazole
Severity: Moderate
Dexamethasone-tobramycin and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially raise systemic dexamethasone levels, increasing corticosteroid effects and adrenal suppression. With topical or ophthalmic use the systemic effect is small.
What this interaction means in plain words
Dexamethasone-tobramycin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4-mediated dexamethasone metabolism.
What to do
With systemic dexamethasone, consider reducing the dose and monitor for corticosteroid excess; no action is needed for minimal-absorption topical use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Levoketoconazole?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially raise systemic dexamethasone levels, increasing corticosteroid effects and adrenal suppression. With topical or ophthalmic use the systemic effect is small.
How serious is the interaction between Dexamethasone-tobramycin and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, consider reducing the dose and monitor for corticosteroid excess; no action is needed for minimal-absorption topical use.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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