Drug interactions
Dexamethasone-tobramycin + Lopinavir
Severity: Moderate
Dexamethasone-tobramycin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and may raise dexamethasone exposure, increasing corticosteroid adverse effects including adrenal suppression. Dexamethasone may also reduce lopinavir levels by CYP3A4 induction, risking reduced antiviral control.
What this interaction means in plain words
Dexamethasone-tobramycin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Lopinavir belongs to Anti Virals.
Why it happens
Lopinavir (with ritonavir) inhibits CYP3A4, while dexamethasone induces CYP3A4, altering each drug's exposure.
What to do
Use the lowest effective dexamethasone dose and duration and monitor for corticosteroid toxicity. Monitor HIV viral load during prolonged co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Lopinavir?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and may raise dexamethasone exposure, increasing corticosteroid adverse effects including adrenal suppression. Dexamethasone may also reduce lopinavir levels by CYP3A4 induction, risking reduced antiviral control.
How serious is the interaction between Dexamethasone-tobramycin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dexamethasone dose and duration and monitor for corticosteroid toxicity. Monitor HIV viral load during prolonged co-therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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