Drug interactions
Dexamethasone-tobramycin + Metolazone
Severity: Moderate
Dexamethasone-tobramycin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and metolazone both increase potassium excretion, and together they can cause significant hypokalemia. Metolazone is potent, so the risk is greater with systemic steroid exposure.
What this interaction means in plain words
Dexamethasone-tobramycin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Metolazone belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid effects and thiazide-like diuresis.
What to do
Monitor serum potassium and magnesium during systemic dexamethasone and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Metolazone
Frequently asked questions
Can I take Dexamethasone-tobramycin with Metolazone?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and metolazone both increase potassium excretion, and together they can cause significant hypokalemia. Metolazone is potent, so the risk is greater with systemic steroid exposure.
How serious is the interaction between Dexamethasone-tobramycin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during systemic dexamethasone and replace as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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