Drug interactions
Dexamethasone-tobramycin + Paromomycin
Severity: Moderate
Dexamethasone-tobramycin and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is poorly absorbed, but in patients with damaged gut mucosa or renal impairment it can be absorbed and add to the nephrotoxicity and ototoxicity of systemic tobramycin. With topical tobramycin the risk is minimal.
What this interaction means in plain words
Dexamethasone-tobramycin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Paromomycin belongs to Anti Bacterial.
Why it happens
Additive aminoglycoside toxicity to renal tubular cells and the inner ear when systemic absorption occurs.
What to do
If systemic tobramycin is used, monitor renal function and hearing, and avoid the combination in renal impairment or inflamed bowel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Paromomycin?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is poorly absorbed, but in patients with damaged gut mucosa or renal impairment it can be absorbed and add to the nephrotoxicity and ototoxicity of systemic tobramycin. With topical tobramycin the risk is minimal.
How serious is the interaction between Dexamethasone-tobramycin and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If systemic tobramycin is used, monitor renal function and hearing, and avoid the combination in renal impairment or inflamed bowel.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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