Drug interactions
Dexamethasone-tobramycin + Rucaparib
Severity: Minor
Dexamethasone-tobramycin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and could raise systemic dexamethasone levels. With ophthalmic dexamethasone the systemic exposure is too small for a meaningful effect. Systemic dexamethasone could produce more steroid effects.
What this interaction means in plain words
Dexamethasone-tobramycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by rucaparib reducing dexamethasone clearance.
What to do
No action is needed for ophthalmic use. With systemic dexamethasone, monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention, and reduce the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Rucaparib?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and could raise systemic dexamethasone levels. With ophthalmic dexamethasone the systemic exposure is too small for a meaningful effect. Systemic dexamethasone could produce more steroid effects.
How serious is the interaction between Dexamethasone-tobramycin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for ophthalmic use. With systemic dexamethasone, monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention, and reduce the dose if needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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