Drug interactions
Dexchlorpheniramine + Doxylamine
Severity: Moderate
Dexchlorpheniramine and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are first-generation sedating antihistamines. Combined use is therapeutic duplication and increases drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion.
What this interaction means in plain words
Dexchlorpheniramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Doxylamine belongs to Respiratory.
Why it happens
Additive H1 receptor blockade and muscarinic antagonism.
What to do
Avoid combining two sedating antihistamines; use only one. Monitor older adults for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxylamine
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Doxylamine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are first-generation sedating antihistamines. Combined use is therapeutic duplication and increases drowsiness and anticholinergic effects such as dry mouth, urinary retention and confusion.
How serious is the interaction between Dexchlorpheniramine and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sedating antihistamines; use only one. Monitor older adults for confusion and urinary retention.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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