Drug interactions
Dexchlorpheniramine + Lorazepam
Severity: Moderate
Dexchlorpheniramine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine that adds to lorazepam-induced drowsiness and psychomotor impairment. Anticholinergic confusion can occur in older adults.
What this interaction means in plain words
Dexchlorpheniramine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1 antagonism.
What to do
Advise patients to avoid driving and alcohol, and consider a non-sedating antihistamine, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Lorazepam?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine that adds to lorazepam-induced drowsiness and psychomotor impairment. Anticholinergic confusion can occur in older adults.
How serious is the interaction between Dexchlorpheniramine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and consider a non-sedating antihistamine, especially in older patients.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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