Drug interactions
Dexchlorpheniramine + Morphine
Severity: Moderate
Dexchlorpheniramine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause greater drowsiness, impaired psychomotor performance and reduced alertness. Respiratory depression is possible at higher opioid doses, and elderly patients are at particular risk.
What this interaction means in plain words
Dexchlorpheniramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor agonism and sedating H1-antihistamine activity.
What to do
Warn patients about sedation and avoid driving or operating machinery. Use the lowest effective doses and monitor sedation and respiratory rate, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Morphine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause greater drowsiness, impaired psychomotor performance and reduced alertness. Respiratory depression is possible at higher opioid doses, and elderly patients are at particular risk.
How serious is the interaction between Dexchlorpheniramine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving or operating machinery. Use the lowest effective doses and monitor sedation and respiratory rate, especially in older adults.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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