Drug interactions
Dexchlorpheniramine + Oxazepam
Severity: Moderate
Dexchlorpheniramine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This sedating antihistamine can add to benzodiazepine-induced drowsiness, slowed reaction times and impaired coordination. Older adults are especially vulnerable to confusion and falls.
What this interaction means in plain words
Dexchlorpheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 receptor blockade and GABA-A potentiation.
What to do
Monitor sedation and counsel against driving or alcohol. Use a non-sedating antihistamine where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Oxazepam?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This sedating antihistamine can add to benzodiazepine-induced drowsiness, slowed reaction times and impaired coordination. Older adults are especially vulnerable to confusion and falls.
How serious is the interaction between Dexchlorpheniramine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel against driving or alcohol. Use a non-sedating antihistamine where feasible.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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