Drug interactions
Dexfenfluramine + Dopamine
Severity: Moderate
Dexfenfluramine and Dopamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic anorectic withdrawn from the market, and combining a sympathomimetic like dopamine with it could cause additive hemodynamic effects. The pair is of mainly historical relevance.
What this interaction means in plain words
Dexfenfluramine and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive sympathomimetic and serotonergic cardiovascular effects.
What to do
Monitor blood pressure and heart rate if the combination is encountered, and titrate dopamine to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dexfenfluramine with Dopamine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Dopamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is a serotonergic anorectic withdrawn from the market, and combining a sympathomimetic like dopamine with it could cause additive hemodynamic effects. The pair is of mainly historical relevance.
How serious is the interaction between Dexfenfluramine and Dopamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if the combination is encountered, and titrate dopamine to the lowest effective dose.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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